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Integrative analyses of genetic characteristics associated with skeletal endothelial cells
Wang, Zhanhui; Hu, Bowen; Chen, Xiaoming; Zhang, Zheng; Liu, Lu; Li, Nan; Liang, Chun.
  • Wang, Zhanhui; Second Affiliated Hospital of Naval Medical University. Department of Cardiology. Shanghai. CN
  • Hu, Bowen; Second Affiliated Hospital of Naval Medical University. Department of Cardiology. Shanghai. CN
  • Chen, Xiaoming; Navy 971st Hospital. Department I of Cadres Ward. Qingdao. CN
  • Zhang, Zheng; Qingdao Special Servicemen Recuperation Center of PLA Navy. Department of Orthopedic Rehabilitation. Qingdao. CN
  • Liu, Lu; Navy 971st Hospital. Department I of Cadres Ward. Qingdao. CN
  • Li, Nan; Navy 971st Hospital. Department I of Cadres Ward. Qingdao. CN
  • Liang, Chun; Second Affiliated Hospital of Naval Medical University. Department of Cardiology. Shanghai. CN
Braz. j. med. biol. res ; 57: e13339, fev.2024. graf
Article in English | LILACS-Express | LILACS | ID: biblio-1557311
ABSTRACT
Abstract The osseous vascular endothelium encompasses a vast intricate framework that regulates bone remodeling. Osteoporosis, an age-associated systemic bone disease, is characterized by the degeneration of the vascular architecture. Nevertheless, the precise mechanisms underpinning the metamorphosis of endothelial cells (ECs) with advancing age remain predominantly enigmatic. In this study, we conducted a systematic analysis of differentially expressed genes (DEGs) and the associated pathways in juvenile and mature femoral ECs, utilizing data sourced from the Gene Expression Omnibus (GEO) repositories (GSE148804) and employing bioinformatics tools. Through this approach, we successfully discerned six pivotal genes, namely Adamts1, Adamts2, Adamts4, Adamts14, Col5a1, and Col5a2. Subsequently, we constructed a miRNA-mRNA network based on miRNAs displaying differential expression between CD31hiEMCNhi and CD31lowEMCNlow ECs, utilizing online repositories for prediction. The expression of miR-466i-3p and miR-466i-5p in bone marrow ECs exhibited an inverse correlation with age. Our in vivo experiments additionally unveiled miR-466i-5p as a pivotal regulator in osseous ECs and a promising therapeutic target for age-related osteoporosis.


Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2024 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Navy 971st Hospital/CN / Qingdao Special Servicemen Recuperation Center of PLA Navy/CN / Second Affiliated Hospital of Naval Medical University/CN

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Full text: Available Index: LILACS (Americas) Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2024 Type: Article / Project document Affiliation country: China Institution/Affiliation country: Navy 971st Hospital/CN / Qingdao Special Servicemen Recuperation Center of PLA Navy/CN / Second Affiliated Hospital of Naval Medical University/CN