Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats
Acta cir. bras
;
31(10): 661-667, Oct. 2016. tab, graf
Article
in English
| LILACS
| ID: biblio-827656
ABSTRACT
ABSTRACT PURPOSE:
To develop a model for studying cerebrovascular disease prevention in elderly women.METHODS:
Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were allocated to a control group. The EA group received estradiol benzoate starting on the 5th day of a 34-day breeding period, and the serum levels of estradiol (E2), estrogen receptor (ER), and malondialdehyde (MDA) were measured. The MCA of each group was then sampled for viscoelastic experiments.RESULTS:
The serum levels of E2 and MDA in the EA group showed significant differences compared to those in the control group (p<0.05), while the difference in ER between the EA and control groups was not significant (p>0.05). The decrease in MCA stress at 7,200 s and the increase in strain at 7,200 s in the EA group showed no significant differences compared to the control group (p>0.05).CONCLUSION:
Estradiol administration inhibited the formation of lipid peroxidation products and restored middle cerebral arterial viscoelasticity in aged female rats.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Middle Cerebral Artery
/
Estradiol
/
Estrogens
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Jilin University/CN
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