The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
Acta cir. bras
;
31(11): 720-723, Nov. 2016. tab, graf
Article
in English
| LILACS
| ID: biblio-827662
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure.METHODS:
60 male, Wistar rats were divided into two tobacco exposure groups a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio.RESULTS:
This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03).CONCLUSIONS:
Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Surgical Flaps
/
Tobacco Smoke Pollution
/
Botulinum Toxins, Type A
/
Graft Survival
/
Neuromuscular Agents
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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