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Osteoarthritis model induced by intra-articular monosodium iodoacetate in rats knee
Morais, Sebastião Vieira de; Czeczko, Nicolau Gregori; Malafaia, Osvaldo; Ribas Filho, Jurandir Marcondes; Garcia, João Batista Santos; Miguel, Marcelo Tizzot; Zini, Cassio; Massignan, Angeline Garcez.
  • Morais, Sebastião Vieira de; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Czeczko, Nicolau Gregori; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Malafaia, Osvaldo; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Ribas Filho, Jurandir Marcondes; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Garcia, João Batista Santos; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Miguel, Marcelo Tizzot; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Zini, Cassio; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
  • Massignan, Angeline Garcez; Universidade Evangélica. Faculdade Evangélica do Paraná. Postgraduate Program in Principles of Surgery. Curitiba. BR
Acta cir. bras ; 31(11): 765-773, Nov. 2016. tab, graf
Article in English | LILACS | ID: biblio-827664
ABSTRACT
ABSTRACT

PURPOSE:

To evaluate the usefulness of a knee osteoarthritis model through functional, radiological and microscopic changes of the synovial membrane.

METHODS:

Forty eight rats were divided randomly into two groups. The first received 0.9% saline in the joint and corresponded to the control group. The second was submitted to experimental osteoarthritis of the right knee induced by monosodium iodoacetate and corresponded to the osteoarthritis group. All animals were subjected to comparative tests of forced ambulation and joint movements, inability to articulate and tactile allodynia on day 1 post-experiment by forced ambulation (Roto-rod test), joint assessment of disability (weight bearing test) and assessment of tactile allodynia (Von Frey test). After inflammatory induction they were divided into four sub-groups corresponding to the scheduled death in 7, 14, 21 and 28 days when they were submitted to radiographic examination of the knee, arthrotomy and collection of the synovial membrane.

RESULTS:

The osteoarthritis group showed significant differences compared to control group on days 7 and 14 in Roto-rod, in weight bearing and Von Frey tests in all days, and in radiological evaluation. Microscopic examination of the synovial membrane showed abnormalities of inflammatory character at all stages.

CONCLUSION:

The osteoarthritis induced by intra-articular monosodium iodoacetate in rats knee is a good model to be used in related research, because it provides mensurable changes on joint movements, tactile allodynia, progressive radiological degeneration and microscopic inflammation of the synovial membrane, that represent markers for osteoarthritis evaluation
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Synovial Membrane / Cartilage, Articular / Osteoarthritis, Knee / Iodoacetic Acid / Knee Joint Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Evangélica/BR

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Full text: Available Index: LILACS (Americas) Main subject: Synovial Membrane / Cartilage, Articular / Osteoarthritis, Knee / Iodoacetic Acid / Knee Joint Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Evangélica/BR