Histological variability and the importance of clinicopathological correlation in cutaneous Rosai-Dorfman disease
An. bras. dermatol
;
91(5): 634-637, Sept.-Oct. 2016. graf
Article
in English
| LILACS
| ID: biblio-827744
ABSTRACT
Abstract Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete clinical response was achieved with thalidomide, followed by recurrence at the initial site one year later. The histological examination displayed the typical features of Rosai-Dorfman disease in the recent lesions but not in the older lesions. In the setting of no lymphadenopathy, the histopathological features of Rosai-Dorfman disease are commonly misinterpreted. Therefore, awareness of the histological aspects present at different stages, not always featuring the hallmark microscopic signs of Rosai-Dorfman disease, is particularly important for a correct diagnosis of this rare disorder.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Skin Diseases
/
Histiocytosis, Sinus
Type of study:
Diagnostic study
Limits:
Adolescent
/
Female
/
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2016
Type:
Article
Affiliation country:
Portugal
Institution/Affiliation country:
Coimbra University Hospital/PT
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