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Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis
Bessa, Giancarlo Rezende; Quinto, Vanessa Petry; Machado, Daiane Corrêa; Lipnharski, Caroline; Weber, Magda Blessmann; Bonamigo, Renan Rangel; D'Azevedo, Pedro Alves.
  • Bessa, Giancarlo Rezende; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Quinto, Vanessa Petry; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Machado, Daiane Corrêa; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Lipnharski, Caroline; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Weber, Magda Blessmann; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • Bonamigo, Renan Rangel; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
  • D'Azevedo, Pedro Alves; Universidade Federal de Ciências da Saúde de Porto Alegre. Porto Alegre. BR
An. bras. dermatol ; 91(5): 604-610, Sept.-Oct. 2016. tab, graf
Article in English | LILACS | ID: biblio-827754
ABSTRACT
Abstract

Background:

Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization.

Objective:

To evaluate the prevalence of Staphylococcus aureus topical antimicrobial drug resistance in atopic dermatitis patients.

Methods:

We conducted a cross-sectional study of children and adults diagnosed with atopic dermatitis and S. aureus colonization. We used miscellaneous literature reported breakpoints to define S. aureus resistance to mupirocin, fusidic acid, gentamicin, neomycin and bacitracin.

Results:

A total of 91 patients were included and 100 S. aureus isolates were analyzed. All strains were methicillin-susceptible S. aureus. We found a low prevalence of mupirocin and fusidic acid resistance (1.1% and 5.9%, respectively), but high levels of neomycin and bacitracin resistance (42.6% and 100%, respectively). Fusidic acid resistance was associated with more severe atopic dermatitis, demonstrated by higher EASI scores (median 17.8 vs 5.7, p=.009). Our results also corroborate the literature on the absence of cross-resistance between the aminoglycosides neomycin and gentamicin.

Conclusions:

Our data, in a southern Brazilian sample of AD patients, revealed a low prevalence of mupirocin and fusidic acid resistance of S. aureus atopic eczema colonizer strains. However, for neomycin and bacitracin, which are commonly used topical antimicrobial drugs in Brazil, high levels of resistance were identified. Further restrictions on the use of these antimicrobials seem necessary to keep resistance as low as possible.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Staphylococcus aureus / Drug Resistance, Bacterial / Dermatitis, Atopic / Anti-Bacterial Agents Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Ciências da Saúde de Porto Alegre/BR

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Full text: Available Index: LILACS (Americas) Main subject: Staphylococcus aureus / Drug Resistance, Bacterial / Dermatitis, Atopic / Anti-Bacterial Agents Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Ciências da Saúde de Porto Alegre/BR