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Coexistence of resistance to thyroid hormone and ectopic thyroid: ten-year follow-up
Guo, Man-Li; Zheng, Xiao; Yang, Liu-Xue; Qiu, Ya-Li; Cheng, Liang; Ma, Shao-Gang.
  • Guo, Man-Li; Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital. Department of Endocrinology and Metabolism. Huai’an. CN
  • Zheng, Xiao; Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital. Department of Endocrinology and Metabolism. Huai’an. CN
  • Yang, Liu-Xue; Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital. Department of Endocrinology and Metabolism. Huai’an. CN
  • Qiu, Ya-Li; Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital. Department of Endocrinology and Metabolism. Huai’an. CN
  • Cheng, Liang; Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital. Department of Endocrinology and Metabolism. Huai’an. CN
  • Ma, Shao-Gang; Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital. Department of Endocrinology and Metabolism. Huai’an. CN
Arch. endocrinol. metab. (Online) ; 60(6): 601-604, Nov.-Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-827794
ABSTRACT
SUMMARY Resistance to thyroid hormone (RTH) coexisting with ectopic thyroid is rare. Here we report a case of RTH with ectopic thyroid. A ten-year-old girl had been misdiagnosed as congenital hypothyroidism and treated with levothyroxine since she was born. Ten-year follow-up showed that the elevated thyrotropin was never suppressed by levothyroxine and no signs indicating hyperthyroidism or hypothyroidism despite elevated FT3 and FT4 levels. Therefore the girl developed no defects in physical and cognitive development. Pituitary adenoma was excluded by magnetic resonance imaging. Ultrasonography did not find the thyroid gland in the normal place, while the thyroid scan found a large lingual thyroid gland. The octreotide inhibition test showed a reduction in thyrotropin by 41.98%. No mutation was detected in the thyroid hormone receptor (THR) β, THRα, thyrotropin receptor (TSHR), and GNAS1 genes. To our knowledge, it is an interesting RTH case coexisting with lingual thyroid.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Receptors, Thyroid Hormone / Thyroid Hormone Resistance Syndrome / Thyroid Dysgenesis Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Child / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Receptors, Thyroid Hormone / Thyroid Hormone Resistance Syndrome / Thyroid Dysgenesis Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Child / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital/CN