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Association of genetic polymorphisms of CISH with the risk of pulmonary tuberculosis in Zahedan, Southeast Iran
Naderi, Mohammad; Hashemi, Mohammad; Safdari, Abolhassan; Bahari, Gholamreza; Taheri, Mohsen.
  • Naderi, Mohammad; Zahedan University of Medical Sciences. Research Center for Infectious Diseases and Tropical Medicine. Zahedan. IR
  • Hashemi, Mohammad; Zahedan University of Medical Sciences. Research Center for Infectious Diseases and Tropical Medicine. Zahedan. IR
  • Safdari, Abolhassan; Zahedan University of Medical Sciences. Research Center for Infectious Diseases and Tropical Medicine. Zahedan. IR
  • Bahari, Gholamreza; Zahedan University of Medical Sciences. Research Center for Infectious Diseases and Tropical Medicine. Zahedan. IR
  • Taheri, Mohsen; Zahedan University of Medical Sciences. Research Center for Infectious Diseases and Tropical Medicine. Zahedan. IR
Braz. j. infect. dis ; 20(4): 379-383, July-Aug. 2016. tab, graf
Article in English | LILACS | ID: biblio-828128
ABSTRACT
Abstract Background In the current study we aimed to find out the impact of cytokine-inducible Src homology 2 domain protein (CISH) gene polymorphisms on the risk of pulmonary tuberculosis (PTB) in a sample of Iranian population. Materials and methods Polymorphisms of CISH rs2239751, rs414171, and rs6768300 were determined in 200 PTB patients and 200 healthy subjects using T-ARMS-PCR or PCR-RFLP method. Results The results showed that rs414171 A>T genotypes significantly decreased the risk of PTB (OR = 0.16, 95% CI = 0.10–0.27, p < 0.0001, AT vs AA; OR = 0.31, 95% CI = 0.14–0.68, p < 0.0001, TT vs AA; OR = 0.19, 95% CI = 0.12–0.29, p < 0.0001, AT+TT vs AA; OR = 0.29, 95%CI = 0.20–0.42, p < 0.0001, T vs A). For rs6768300, the findings indicated that this variant decreased the risk of PTB (OR = 0.52, 95% CI = 0.33–0.82, p = 0.005, CG vs GG; OR = 0.57, 95% CI = 0.38–0.87, p = 0.012, C vs G). No significant association was observed between CISH rs2239751 polymorphism and risk/protection of PTB. Conclusion Our findings indicated that CISH rs414171 and rs6768300 variants might be associated with protection from PTB.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / Genetic Predisposition to Disease / Suppressor of Cytokine Signaling Proteins Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: Iran Institution/Affiliation country: Zahedan University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / Genetic Predisposition to Disease / Suppressor of Cytokine Signaling Proteins Type of study: Etiology study / Observational study / Risk factors Limits: Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: Iran Institution/Affiliation country: Zahedan University of Medical Sciences/IR