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Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population
Yuan, Jun; Zhang, Yan; Yan, Fu-tang; Zheng, Xiao.
  • Yuan, Jun; Shaanxi Provincial People's Hospital. Clinical Laboratory. Xi’an. CN
  • Zhang, Yan; Shaanxi Provincial People's Hospital. Clinical Laboratory. Xi’an. CN
  • Yan, Fu-tang; Shaanxi Provincial People's Hospital. Clinical Laboratory. Xi’an. CN
  • Zheng, Xiao; Shaanxi Provincial People's Hospital. Clinical Laboratory. Xi’an. CN
Braz. j. infect. dis ; 20(6): 564-568, Nov.-Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-828158
ABSTRACT
ABSTRACT

Objective:

Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study.

Methods:

We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54.2 years). All the subjects were unrelated individuals of Chinese Han Population. Three SNPs of PRKAA1gene were tested.

Results:

Rs1002424 polymorphism showed significant difference in the allele frequencies, but no difference in the genotype frequencies (allele p = 0.039411, OR95%CI = 0.783479 [0.621067-0.988362]; genotype p = 0.104758); rs13361707 polymorphism showed significance in allele analysis, but not in genotype analysis (allele p = 0.034749, OR95%CI = 1.284303 [1.017958-1.620335]; genotype p = 0.098027); rs3792822 polymorphism was demonstrated to have significant differences in both genotype and allele frequencies between cases and controls (allele p = 0.029286, OR95%CI= 0.741519 [0.566439-0.970716]; genotype p = 0.034560). The haplotype results showed that CTG and TCA in the rs13361707-rs1002424-rs3792822 block were significantly associated with the happening of HBV (CTG p = 0.036854, OR95%CI = 1.281 [1.015-1.617]; p = 0.030841, OR95%CI = 0.743 [0.568-0.973]).

Conclusion:

These findings suggest that PRKAA1 polymorphisms may contribute to the susceptibility of chronic HBV infection in Chinese Han origin.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Hepatitis B, Chronic / Genetic Predisposition to Disease / AMP-Activated Protein Kinases Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Shaanxi Provincial People's Hospital/CN

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Hepatitis B, Chronic / Genetic Predisposition to Disease / AMP-Activated Protein Kinases Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Shaanxi Provincial People's Hospital/CN