To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori
Braz. j. infect. dis
;
20(6): 534-538, Nov.-Dec. 2016. tab, graf
Article
in English
| LILACS
| ID: biblio-828170
ABSTRACT
ABSTRACT Objective:
The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen.Methods:
In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software.Results:
Mean ages and SD were 38.8 ± 10.9 and 40.1 ± 10.4 for the study and control groups, respectively, statistically similar. Peptic ulcer was found in 30% of both groups. Response to treatment was 83.3% and 62.5% in the study and control groups, respectively. This difference was statistically significant.Conclusion:
Addition of licorice to the triple clarithromycin-based regimen increases H. pylori eradication, especially in the presence of peptic ulcer disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plant Extracts
/
Helicobacter pylori
/
Helicobacter Infections
/
Clarithromycin
/
Glycyrrhiza
/
Anti-Bacterial Agents
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2016
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Qazvin University of Medical Sciences/IR
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