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Characteristics and thermodynamics of the interaction of 6-shogaol with human serum albumin as studied by isothermal titration calorimetry
Feroz, Shevin Rizal; Malek, Sri Nurestri Abdul; Tayyab, Saad.
  • Feroz, Shevin Rizal; University of Malaya. Faculty of Science. Institute of Biological Sciences. Kuala Lumpur. MY
  • Malek, Sri Nurestri Abdul; University of Malaya. Faculty of Science. Institute of Biological Sciences. Kuala Lumpur. MY
  • Tayyab, Saad; University of Malaya. Faculty of Science. Institute of Biological Sciences. Kuala Lumpur. MY
Braz. j. pharm. sci ; 52(3): 443-446, July-Sept. 2016. tab, graf
Article in English | LILACS | ID: biblio-828257
ABSTRACT
ABSTRACT The interaction between 6-shogaol, a pharmacologically active ginger constituent, and human serum albumin (HSA), the main in vivo drug transporter, was investigated using isothermal titration calorimetry (ITC). The value of the binding constant, Ka (5.02 ± 1.37 × 104 M−1) obtained for the 6-shogaol-HSA system suggested intermediate affinity. Analysis of the ITC data revealed feasibility of the binding reaction due to favorable enthalpy and entropy changes. The values of the thermodynamic parameters suggested involvement of van der Waals forces, hydrogen bonds and hydrophobic interactions in the 6-shogaol-HSA complex formation.
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Full text: Available Index: LILACS (Americas) Main subject: Thermodynamics / Ginger Language: English Journal: Braz. j. pharm. sci Year: 2016 Type: Article / Project document Affiliation country: Malaysia Institution/Affiliation country: University of Malaya/MY

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Full text: Available Index: LILACS (Americas) Main subject: Thermodynamics / Ginger Language: English Journal: Braz. j. pharm. sci Year: 2016 Type: Article / Project document Affiliation country: Malaysia Institution/Affiliation country: University of Malaya/MY