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Molecular evidence of high-risk human papillomavirus infection in colorectal tumours from Cuban patients
Soto, Yudira; Limia, Celia Maria; González, Licet; Grá, Bienvenido; Hano, Olga Marina; Martínez, Pedro Ariel; Kourí, Vivian.
  • Soto, Yudira; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
  • Limia, Celia Maria; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
  • González, Licet; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
  • Grá, Bienvenido; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
  • Hano, Olga Marina; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
  • Martínez, Pedro Ariel; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
  • Kourí, Vivian; Institute of Tropical Medicine Pedro Kourí. Department of Virology. Laboratory of Sexually Transmitted Diseases. La Habana. CU
Mem. Inst. Oswaldo Cruz ; 111(12): 731-736, Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-829255
ABSTRACT
The association between colorectal cancer and human papillomavirus (HPV) infection is still unproven. The aim of this study was to investigate the presence of high-risk HPV (HR-HPV) DNA in colorectal tissues from Cuban patients. A total of 63 colorectal formalin-fixed paraffin-embedded tissues were studied (24 adenocarcinoma, 18 adenoma, and 21 colorectal tissues classified as benign colitis). DNA from colorectal samples was analysed by quantitative real-time polymerase chain reaction to detect the most clinically relevant high HR-HPV types (HPV-16, -18, -31, -33, -45, -52, and -58). Associations between histologic findings and other risk factors were also analysed. Overall, HPV DNA was detected in 23.8% (15/63) of the samples studied. Viral infections were detected in 41.7% of adenocarcinoma (10/24) and 27.7% of adenoma cases (5/18). HPV DNA was not found in any of the negative cases. An association between histological diagnosis of adenocarcinoma and HPV infection was observed (odd ratio = 4.85, 95% confidence interval = 1.40-16.80, p = 0.009). The only genotypes identified were HPV 16 and 33. Viral loads were higher in adenocarcinoma, and these cases were associated with HPV 16. This study provides molecular evidence of HR-HPV infection in colorectal adenocarcinoma tissues from Cuban patients.
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Full text: Available Index: LILACS (Americas) Main subject: Papillomaviridae / DNA, Viral / Colorectal Neoplasms / Adenocarcinoma / Adenoma / Papillomavirus Infections Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: Caribbean / Cuba Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Cuba Institution/Affiliation country: Institute of Tropical Medicine Pedro Kourí/CU

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Full text: Available Index: LILACS (Americas) Main subject: Papillomaviridae / DNA, Viral / Colorectal Neoplasms / Adenocarcinoma / Adenoma / Papillomavirus Infections Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: Caribbean / Cuba Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Cuba Institution/Affiliation country: Institute of Tropical Medicine Pedro Kourí/CU