Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
Rev. bras. farmacogn
;
26(6): 701-704, Nov.-Dec. 2016. tab, graf
Article
in English
| LILACS
| ID: biblio-829922
ABSTRACT
ABSTRACT Phytochemical investigation of the MeOH extract of Cucumis melo L. var. reticulates, Cucurbitaceae, seeds led to the isolation of a new triterpenoid cucumol A (27-hydroxy taraxerol-3β-ol), along with three known compounds α-spinasterol and DB-friedoolean-5-ene-3-β-ol. Their structures were established by extensive 1D (1H, 13C, and DEPT) and 2D (1H–1H COSY, HMQC, and HMBC) NMR, as well as IR and HRESIMS spectral analyses. Compound 3 displayed cytotoxic activity against L5178Y and Hela cancer cell lines with ED50 of 1.30 and 5.40 µg/ml, respectively compared to paclitaxel (0.07 and 0.92 µg/ml, respectively).
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2016
Type:
Article
/
Project document
Affiliation country:
Saudi Arabia
Institution/Affiliation country:
Taibah University/SA
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