Hiperinsulinemia y resistencia insulínica en niños de dos escuelas públicas de Oaxaca, México / Hyperinsulinemia and insulin resistance in children
Rev. méd. Chile
;
144(8): 1020-1028, ago. 2016. graf, tab
Article
in Spanish
| LILACS
| ID: biblio-830608
ABSTRACT
Background:
Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood.Aim:
To measure insulin and glucose levels and parameters of insulin resistance in obese, overweight and normal weight Mexican children. Material andMethods:
Comparative study of 21 obese children with a body mass index (BMI) over percentile 95, aged 10 ± 1 years (10 males), 14 children aged 10 ± 2 (7 males) with a BMI between percentiles 85 and 94 and 16 children aged 9 ± 2 years (3 males) with a body mass index between percentiles 10 and 84. Body weight, blood pressure and waist circumference were measured and a blood sample was obtained to measure fasting glucose and insulin levels. Homeostasis model of insulin resistance (HOMA) and quantitative insulin sensitivity check index (QUICKI) were calculated.Results:
Among obese, overweight and normal weight children, insulin levels were 14.9 (95% CI 10.90-18.99), 7.20 (CI 5.12-9.28) and 4.73 (CI 95% 1.92-7.53) uU/ml, respectively. The figures for HOMA were 3.16 (95% CI 2.20-4.12), 1.49 (95% CI 1.03-1.94) and 0.97 (95% CI 0.35-1.60), respectively. The figures for QUICKI were 0.331 (95% CI 0.319-0.343), 0.371 (95% CI 0.349-0.393) and 0.419 (95% CI 0.391-0.446), respectively. Compared to their normal weight counterparts, the risk of obese children and those with a waist circumference over percentile 90 of having a HOMA over 3.16 was 17 and 10 times higher, respectively. BMI correlated better than waist circumference with insulin levels.Conclusions:
Obese children have higher levels of insulin resistance than their normal weight counterparts.
Full text:
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Index:
LILACS (Americas)
Main subject:
Insulin Resistance
/
Hyperinsulinism
/
Insulin
/
Obesity
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2016
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Universidad Autónoma Benito Juárez de Oaxaca/MX
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