Blood transfusion-related immunomodulation
Clin. biomed. res
;
34(4): 333-341, 2014. ilus, tab
Article
in English
| LILACS
| ID: biblio-834486
ABSTRACT
The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood Group Antigens
/
Blood Preservation
/
Blood Transfusion
/
Immunosuppression Therapy
/
Transplantation Tolerance
/
Leukocyte Reduction Procedures
/
Immunomodulation
/
HLA Antigens
Language:
English
Journal:
Clin. biomed. res
Journal subject:
Medicine
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital de Clínicas de Porto Alegre/BR
/
Universidade Federal do Rio Grande do Sul/BR
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