Primary myelofibrosis: current therapeutic options
Rev. bras. hematol. hemoter
;
38(3): 257-263, 2016. tabela, figura
Article
in English
| LILACS
| ID: biblio-837123
ABSTRACT
Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia. In addition, disabling constitutional symptoms secondary to the high circulating levels of proinflammatory cytokines and hepatosplenomegaly frequently impair quality of life. Herein the main current treatment options for primary myelofibrosis patients are discussed, contemplating disease-modifying therapeutics in addition to palliative measures, in an individualized patient-based approach:
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Janus Kinase 2
/
Primary Myelofibrosis
/
Myeloproliferative Disorders
Limits:
Humans
Language:
English
Journal:
Rev. bras. hematol. hemoter
Journal subject:
Hematology
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Campinas/BR
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