Therapeutic effect of low molecular weight chitosan containing sepia ink on ethanol-induced gastric ulcer in rats
Acta cir. bras
;
31(12): 813-820, Dec. 2016. graf
Article
in English
| LILACS
| ID: biblio-837660
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the role of low molecular chitosan containing sepia ink (LMCS) in ethanol-induced (5 ml/kg) gastric ulcer in rats.METHODS:
Animals were divided into four groups (n = 12) normal group (Normal), negative control group (Con), experiment group (LMCS) and positive control Omeprazole group (OMZ). Gastric empty rate was detected in the first 7 days. Rats were sacrificed at 7, 14 and 21 day for histology and ELISA detections.RESULTS:
Gastric empty was no significant differences among the groups (P > 0.05). Histological observation showed gastric mucosal LMCS treated had better healing effect. Hydroxyproline (Hyp) was significantly increased from 7 day (P < 0.05). LMCS significantly inhibited malondialdehyde (MDA) generation for lipid peroxidation from 7 day (P < 0.05). LMCS significantly promoted the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) at the earlier stage (P < 0.05). OMZ had the similar effects above. As for myeloperoxidase (MPO), LMCS significantly decreased and restored it to normal levels from 7 day (P < 0.05), it is earlier than OMZ which is from 14 day.CONCLUSION:
LMCS can improve gastric mucosa tissue repair, exert significant influences on oxidative and antioxidant enzyme activities and neutrophil infiltration.
Full text:
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Index:
LILACS (Americas)
Main subject:
Stomach Ulcer
/
Chitosan
/
Sepia
/
Gastric Mucosa
/
Anti-Ulcer Agents
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Lingnan Normal University/CN
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