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The renoprotective effect of oral Tadalafil pretreatment on ischemia/reperfusion injury in rats
Medeiros, Vanessa de Fátima Lima Paiva; Azevedo, Ítalo Medeiros; Carvalho, Marília Daniela Ferreira; Oliveira, Cláudia Nunes; Egito, Eryvaldo Sócrates Tabosa do; Medeiros, Aldo Cunha.
  • Medeiros, Vanessa de Fátima Lima Paiva; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Azevedo, Ítalo Medeiros; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Carvalho, Marília Daniela Ferreira; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Oliveira, Cláudia Nunes; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Egito, Eryvaldo Sócrates Tabosa do; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Medeiros, Aldo Cunha; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
Acta cir. bras ; 32(2): 90-97, Feb. 2017. tab, graf
Article in English | LILACS | ID: biblio-837678
ABSTRACT
Abstract

Purpose:

To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats

Methods:

Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performed

Results:

Better tissue perfusion was lower in ischemic left/kidney than in right/kidney in saline group, suggesting reduced kidney clearance. Fluorescence in left/kidneys of tadalafil treated rats was lower than in right/kidneys (difference not significant). The fluorescence signal intensity in kidneys of tadafil treated rats was higher than in saline rats. TNF-α levels were significantly lower in I/R tadalafil group rats compared to I/R saline group (154±10.3 vs 391.3±12.3), as well as IL-1β (163.4±13.2 vs 279±11.5pg/dL), and IL-6 (122.9±8.1 vs 173.7±6.3 respectively; p=0.0001). Urea, creatinine and C-reactive protein were significantly lower in tadafil treated rats then in saline group

Conclusion:

Tadalafil therapy decreased the expression of circulating pro-inflammatory cytokines in a renal I/R rodent model, while improving kidney function proofs.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Vasodilator Agents / Reperfusion Injury / Tadalafil / Kidney Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Norte/BR

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Full text: Available Index: LILACS (Americas) Main subject: Vasodilator Agents / Reperfusion Injury / Tadalafil / Kidney Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Rio Grande do Norte/BR