Short-term buserelin administration induces apoptosis and morphological changes in adult rat testes
Acta cir. bras
;
32(2): 140-147, Feb. 2017. graf
Article
in English
| LILACS
| ID: biblio-837680
ABSTRACT
Abstract Purpose:
To investigate the effect of buserelin on gonadal structure and function in adult male rats.Methods:
Twenty-four adult Wistar male rats were divided into three groups two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days.Results:
The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups.Conclusion:
Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Seminiferous Tubules
/
Buserelin
/
Apoptosis
/
Fertility Agents, Male
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Urmia University of Medical Sciences/IR
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