Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
Acta cir. bras
;
32(3): 229-235, Mar. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-837690
ABSTRACT
Abstract Purpose:
To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress.Methods:
Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion.Results:
Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue.Conclusion:
Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tramadol
/
Reperfusion Injury
/
Oxidative Stress
/
Ischemic Preconditioning
/
Protective Agents
/
Ischemia
/
Kidney
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual do Pará/BR
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