Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
Acta cir. bras
; Acta cir. bras;32(3): 229-235, Mar. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-837690
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress.Methods:
Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion.Results:
Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue.Conclusion:
Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.Key words
Full text:
1
Index:
LILACS
Main subject:
Tramadol
/
Reperfusion Injury
/
Oxidative Stress
/
Ischemic Preconditioning
/
Protective Agents
/
Ischemia
/
Kidney
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article