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The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats
Orhan, Erkan; Uysal, Ahmet Çağrı; Başer, Engin; Keskin, Dürdane; Demiroğlu-Yakut, Çiğdem.
  • Orhan, Erkan; Namik Kemal University. Department of Plastic Surgery. Tekirdağ. TR
  • Uysal, Ahmet Çağrı; Namik Kemal University. Department of Plastic Surgery. Tekirdağ. TR
  • Başer, Engin; Namik Kemal University. Department of Plastic Surgery. Tekirdağ. TR
  • Keskin, Dürdane; Namik Kemal University. Department of Plastic Surgery. Tekirdağ. TR
  • Demiroğlu-Yakut, Çiğdem; Namik Kemal University. Department of Plastic Surgery. Tekirdağ. TR
Acta cir. bras ; 32(4): 280-286, Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-837700
ABSTRACT
Abstract

Purpose:

To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability.

Methods:

Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats. For precluding vascularization from the base, a silicone layer was placed under the flap in groups 2(only flap+silicone), 4(saline+silicone) and 6(PRP+silicone). In groups 1(only flap), 2(only flap+silicone) nothing was done except flap surgery. In groups 3(saline) and 4(saline+silicone), saline was applied intradermally , in groups 5(PRP) and 6(PRP+silicone), inactive form of PRP which obtained from different 16 rats was applied intradermally, into certain points of flaps immediately after surgery. After 7 days flap necrosis ratio was measured in all groups.

Results:

Mean necrosis rate in group 5(PRP) (16.05%) was statistically significantly lower than group 1(only flap) (31,93%) and group 3(saline) (30,43%) (p<0.001). Mean necrosis rate in group 6(PRP+silicone) (36.37%) was statistically significantly lower than group 2(only flap+silicone) (47.93%) and group 4(saline+silicone) (45.65%) (p<0.001).

Conclusion:

Intradermal inactive platelet rich plasma administration decreases flap necrosis so for skin application.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Surgical Flaps / Injections, Intradermal / Platelet-Rich Plasma / Graft Survival Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Namik Kemal University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Surgical Flaps / Injections, Intradermal / Platelet-Rich Plasma / Graft Survival Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Namik Kemal University/TR