Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator
Acta cir. bras
;
32(4): 319-324, Apr. 2017. graf
Article
in English
| LILACS
| ID: biblio-837703
ABSTRACT
Abstract Purpose:
To describe a new model of actinic enteritis that does not use radiotherapy machines.Methods:
Sixteen Wistar rats were divided into four groups, consisting of four animals each control (group A), two weeks after irradiation (group B), five weeks after irradiation (group C) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal.Results:
In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon.Conclusion:
We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Radiation Injuries, Experimental
/
Cobalt Radioisotopes
/
Colon
/
Dose-Response Relationship, Radiation
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Minas Gerais/BR
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