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Creation of a contusion injury method for skeletal muscle in rats with differing impacts
Dantas, Milla Gabriela Belarmino; Damasceno, Camila Mahara Dias; Barros, Vanessa Raquel Pinto de; Menezes, Eveline Soares; Fontoura, Humberto de Sousa; Lima, Ricardo Santana de; Carvalho, Ferdinando Oliveira; Almeida, Jackson Roberto Guedes da Silva.
  • Dantas, Milla Gabriela Belarmino; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Damasceno, Camila Mahara Dias; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Barros, Vanessa Raquel Pinto de; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Menezes, Eveline Soares; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Fontoura, Humberto de Sousa; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Lima, Ricardo Santana de; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Carvalho, Ferdinando Oliveira; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
  • Almeida, Jackson Roberto Guedes da Silva; Universidade Federal do Vale do São Francisco. Center for Studies and Research of Medicinal Plants. Postgraduate Program in Health and Biological Sciences. Petrolina. BR
Acta cir. bras ; 32(5): 369-375, May 2017. tab, graf
Article in English | LILACS | ID: biblio-837706
ABSTRACT
Abstract

Purpose:

To realize a morphological examination of the musculoskeletal tissue, assessing the effect of a contusion method for the production in rat gastrocnemius, comparing the inflammatory responses generated by different impacts.

Methods:

For the analysis of a contusion method, twelve female Wistar rats were distributed into four groups. The lesion was generated by 324 g of mass that was dropped from different predetermined heights for each group (30, 45, 60 and 70 cm).

Results:

In the analysis of musculoskeletal tissue, the response to injury varied according to the mass of the height drop onto the muscle. Only the group that was injured from 70 cm responded with uniform and severe inflammation, whereas the groups 30, 45 and 60 cm showed inflammation in some regions of the tissue with mild and moderate infiltrates.

Conclusion:

The method with the 324-gram mass dropped from a 70-cm height onto the gastrocnemius muscle of rats seems to be the most suitable for the production of muscle injury in these animals after 72 hours, showing an important inflammatory infiltrate.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Muscle, Skeletal / Contusions / Disease Models, Animal Type of study: Etiology study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Vale do São Francisco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Muscle, Skeletal / Contusions / Disease Models, Animal Type of study: Etiology study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Vale do São Francisco/BR