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Propofol attenuates cytokine-mediated upregulation of expression of inducible nitric oxide synthase and apoptosis during regeneration post-partial hepatectomy
Yagmurdur, Hatice; Binnetoglu, Kenan; Astarci, Hesna Muzeyyen; Yagmurdur, Mahmut Can.
  • Yagmurdur, Hatice; Kafkas University. School of Medicine. Department of Anesthesiology and Reanimation. Kars. TR
  • Binnetoglu, Kenan; Kafkas University. School of Medicine. Department of Anesthesiology and Reanimation. Kars. TR
  • Astarci, Hesna Muzeyyen; Kafkas University. School of Medicine. Department of Anesthesiology and Reanimation. Kars. TR
  • Yagmurdur, Mahmut Can; Kafkas University. School of Medicine. Department of Anesthesiology and Reanimation. Kars. TR
Acta cir. bras ; 32(5): 396-406, May 2017. tab, graf
Article in English | LILACS | ID: biblio-837708
ABSTRACT
Abstract

Purpose:

To determine the effects of propofol and ketamine anesthesia on liver regeneration in rats after partial hepatectomy (PHT).

Methods:

Male Wistar albino rats were assigned randomly to four groups of 10. Anesthesia was induced and maintained with propofol in groups 1 and 2, and with ketamine in groups 3 and 4. PHT was undertaken in groups 1 and 3. Rats in groups 2 and 4 (control groups) underwent an identical surgical procedure, but without PHT. At postoperative day-5, rats were killed. Regenerated liver was removed, weighed, and evaluated (by immunohistochemical means) for expression of inducible nitric oxide synthase (iNOS), endothelial NOS (eNOS), apoptosis protease-activating factor (APAF)-1, and proliferating cell nuclear antigen (PCNA). Also, blood samples were collected for measurement of levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6.

Results:

Between groups 2 and 4, there were no differences in tissue levels of iNOS, eNOS, and APAF-1 or plasma levels of TNF-α and IL-6. eNOS expression was similar in group 1 and group 3. Expression of iNOS and APAF-1 was mild-to-moderate in group 1, but significantly higher in group 3. Groups 1 and 3 showed an increase in PCNA expression, but expression in both groups was comparable. Plasma levels of TNF-α and IL-6 increased to a lesser degree in group 1 than in group 3.

Conclusion:

Propofol, as an anesthetic agent, may attenuate cytokine-mediated upregulation of iNOS expression and apoptosis in an animal model of liver regeneration after partial hepatectomy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Propofol / Apoptosis / Anesthetics, Intravenous / Nitric Oxide Synthase Type II / Ketamine / Liver Regeneration Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Kafkas University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Propofol / Apoptosis / Anesthetics, Intravenous / Nitric Oxide Synthase Type II / Ketamine / Liver Regeneration Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Kafkas University/TR