Multiple cutaneous melanomas associated with gastric and brain metastases
An. bras. dermatol
;
91(5,supl.1): 98-100, Sept.-Oct. 2016. tab, graf
Article
in English
| LILACS
| ID: biblio-837940
ABSTRACT
Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Skin Neoplasms
/
Stomach Neoplasms
/
Brain Neoplasms
/
Melanoma
/
Neoplasms, Multiple Primary
Type of study:
Prognostic study
/
Risk factors
Limits:
Aged
/
Humans
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado do Rio de Janeiro/BR
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