Angiosarcoma in HIV-negative patients is not associated with HHV-8
An. bras. dermatol
;
91(6): 738-741, Nov.-Dec. 2016. tab, graf
Article
in English
| LILACS
| ID: biblio-837975
ABSTRACT
Abstract BACKGROUND:
Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.OBJECTIVE:
To investigate the relationship between the presence of HHV-8 and angiosarcoma.METHODS:
In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.RESULTS:
While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.CONCLUSION:
These findings support most previous studies that found no association between HHV-8 and angiosarcoma.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sarcoma, Kaposi
/
Skin Neoplasms
/
AIDS-Related Opportunistic Infections
/
HIV Seronegativity
/
Herpesvirus 8, Human
/
Hemangiosarcoma
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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