Effects of isotretinoin on the olfactory function in patients with acne
An. bras. dermatol
;
92(2): 191-195, Mar.-Apr. 2017. graf
Article
in English
| LILACS
| ID: biblio-838051
ABSTRACT
Abstract Background:
Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice.Objective:
This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy.Methods:
Forty-five patients (aged 25-40 years) with acne were included in the study. All patients underwent a rhinological examination. Olfactory function was assessed by the Sniffin' Sticks Test. The test was assessed at baseline and in the third month of isotretinoin treatment.Results:
Isotretinoin improved the performance of patients in the olfactory test. The SST score increased from 8.7±1.09 to 9.5±1.19 (p<0.001), prevalence of hyposmia decreased from 40% to 24% and normosmia increased from 60% to 75% (p=0.059). The percentage of patients whose olfactory function was categorized as "good" increased from 6% to 21.3%. This increase was statistically significant (p<0.05). Studylimitations:
Absence of a control group is one of the limitations of this study. Also, we did not evaluate patients with smell test after stopping isotretinoin treatment.Conclusion:
We examined the effect of systemic isotretinoin on olfactory function. It can be concluded from the present investigation that isotretinoin therapy improves the sense of smell.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Smell
/
Tretinoin
/
Isotretinoin
/
Acne Vulgaris
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2017
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Erciyes University/TR
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