Metastatic Lymphoepithelioma-like Hepatocellular Carcinoma: a Potential Diagnostic Pitfall and Demonstration of Pd-l1 Expression
Ann. hepatol
;
16(1): 157-159, Jan.-Feb. 2017. graf
Article
in English
| LILACS
| ID: biblio-838098
ABSTRACT
Abstract Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a rare primary hepatic neoplasm with female predominance and relatively good prognosis. We report a 73-year-old female with chronic hepatitis B who developed metastatic lesions 5 years after underwent resection for LEL-HCC. The metastatic lesions showed a spectrum of morphologic findings, which could be mistaken for other entities such as lymphoma, particularly in lesions with single-cell infiltrative pattern and abundant tumor-infiltrating lymphocytes. Immunohistochemical study to confirm the origin of the neoplastic cells is important to make the diagnosis. We also highlighted the clinicopathologic correlation and potential therapeutic implication of programmed death ligand-1 expression in LEL-HCC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biomarkers, Tumor
/
Carcinoma, Hepatocellular
/
B7-H1 Antigen
/
Liver Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Ann. hepatol
Journal subject:
Gastroenterology
Year:
2017
Type:
Article
Affiliation country:
United States
Institution/Affiliation country:
Icahn School of Medicine at Mount Sinai/US
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