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Body composition, resting energy expenditure and inflammatory markers: impact in users of depot medroxyprogesterone acetate after 12 months follow-up
Batista, Gisele Almeida; Souza, Aglécio Luiz de; Marin, Daniela Miguel; Sider, Marina; Melhado, Vaneska Carvalho; Fernandes, Arlete Maria; Alegre, Sarah Monte.
  • Batista, Gisele Almeida; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Souza, Aglécio Luiz de; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Marin, Daniela Miguel; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Sider, Marina; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Melhado, Vaneska Carvalho; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Fernandes, Arlete Maria; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
  • Alegre, Sarah Monte; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Campinas. BR
Arch. endocrinol. metab. (Online) ; 61(1): 70-75, Jan.-Feb. 2017. tab, graf
Article in English | LILACS | ID: biblio-838419
ABSTRACT
ABSTRACT Objective The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed. Results After 12 months of evaluation, we could observe a significant increase in the DMPA group in weight (3,01 kg) and BMI, while the IUD group’s only significant increase was observed in the BMI. Relative to REE there was an increase of basal metabolic rate (BMR) in both groups after one year. The sub-group DMPA that gained < 3 kg had increased significant weight, BMI and body surface (BS) with respiratory quotient (RQ) reduction, while the sub-group that gained ≥ 3 kg had a significant increase in weight, BMI, BS, fat-free mass, fat mass, BMR, Leptin, HOMA-IR and waist circumference, with RQ significantly reduced. Conclusion Our study found significant changes in weight, body composition and metabolic profile of the population studied in the first 12 months of contraceptive use. These changes mainly increased body weight, leptin levels and HOMA-IR which can contribute to the development of some chronic complications, including obesity, insulin resistance and diabetes mellitus.
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Full text: Available Index: LILACS (Americas) Main subject: Body Composition / Biomarkers / Weight Gain / Medroxyprogesterone Acetate / Energy Metabolism Type of study: Health economic evaluation / Observational study / Prognostic study Limits: Adult / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Body Composition / Biomarkers / Weight Gain / Medroxyprogesterone Acetate / Energy Metabolism Type of study: Health economic evaluation / Observational study / Prognostic study Limits: Adult / Female / Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR