Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review
Arch. endocrinol. metab. (Online)
;
61(2): 198-201, Mar.-Apr. 2017. tab
Article
in English
| LILACS
| ID: biblio-838424
ABSTRACT
SUMMARY Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis.
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Index:
LILACS (Americas)
Main subject:
Pancreatitis
/
Heparin
/
Hypertriglyceridemia
/
Hypoglycemic Agents
/
Insulin
/
Anticoagulants
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2017
Type:
Article
Affiliation country:
India
Institution/Affiliation country:
Division of Endocrinology and Diabetes, Medanta/IN
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