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Estimation of cardiovascular risk and detection of subclinical carotid atheromatosis in patients with diabetes without a history of cardiovascular disease
Masson, Walter; Francesca, Salvador De; Molinero, Micaela; Siniawski, Daniel; Mulassi, Andrés; Morales, Frank Espinoza; Huerin, Melina; Lobo, Martín; Molinero, Graciela.
  • Masson, Walter; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Francesca, Salvador De; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Molinero, Micaela; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Siniawski, Daniel; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Mulassi, Andrés; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Morales, Frank Espinoza; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Huerin, Melina; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Lobo, Martín; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
  • Molinero, Graciela; Council of Epidemiology and Cardiovascular Prevention. Buenos Aires. AR
Arch. endocrinol. metab. (Online) ; 61(2): 122-129, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-838437
ABSTRACT
ABSTRACT Objectives Cardiovascular risk estimated by several scores in patients with diabetes mellitus without a cardiovascular disease history and the association with carotid atherosclerotic plaque (CAP) were the aims of this study. Materials and methods Cardiovascular risk was calculate using United Kingdom Prospective Diabetes Study (UKPDS) risk engine, Framingham risk score for cardiovascular (FSCV) and coronary disease (FSCD), and the new score (NS) proposed by the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol. Ultrasound was used to assess CAP occurrence. A receiver operating characteristic (ROC) analysis was performed. Results One hundred seventy patients (mean age 61.4 ± 11 years, 58.8% men) were included. Average FSCV, FSCD and NS values were 33.6% ± 21%, 20.6% ± 12% and 24.8% ± 18%, respectively. According to the UKPDS score, average risk of coronary disease and stroke were 22.1% ± 16% and 14.3% ± 19% respectively. Comparing the risks estimated by the different scores a significant correlation was found. The prevalence of CAP was 51%, in patients with the higher scores this prevalence was increased. ROC analysis showed a good discrimination power between subjects with or without CAP. Conclusion The cardiovascular risk estimated was high but heterogenic. The prevalence of CAP increased according to the strata of risk. Understanding the relationship between CAP and scores could improve the risk estimation in subjects with diabetes.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carotid Artery Diseases / Risk Assessment / Diabetes Complications / Plaque, Atherosclerotic Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Practice guideline / Observational study / Prevalence study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Argentina Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Argentina Institution/Affiliation country: Council of Epidemiology and Cardiovascular Prevention/AR

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Full text: Available Index: LILACS (Americas) Main subject: Carotid Artery Diseases / Risk Assessment / Diabetes Complications / Plaque, Atherosclerotic Type of study: Controlled clinical trial / Diagnostic study / Etiology study / Practice guideline / Observational study / Prevalence study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Argentina Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2017 Type: Article Affiliation country: Argentina Institution/Affiliation country: Council of Epidemiology and Cardiovascular Prevention/AR