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Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis / Efeito da imunoterapia sublingual sobre a atividade plaquetária em crianças com rinite alérgica
Chen, Yanqiu; Zhou, Lifeng; Yang, Yan.
  • Chen, Yanqiu; Guangzhou Medical College. Guangzhou Women and Children's Medical Center. Department of Otolaryngology. Guangzhou. CN
  • Zhou, Lifeng; Guangzhou Medical College. Guangzhou Women and Children's Medical Center. Department of Otolaryngology. Guangzhou. CN
  • Yang, Yan; Guangzhou Medical College. Guangzhou Women and Children's Medical Center. Department of Otolaryngology. Guangzhou. CN
Braz. j. otorhinolaryngol. (Impr.) ; 83(2): 190-194, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-839433
ABSTRACT
Abstract

Introduction:

The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms.

Objective:

The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis.

Methods:

Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay.

Results:

Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related.

Conclusion:

During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy.
RESUMO
Resumo

Introdução:

O papel da ativação de plaquetas na inflamação alérgica recebeu atenção crescente. A imunoterapia sublingual para rinite alérgica pode modificar o processo imunológico a um alérgeno, em vez de tratar os sintomas simplesmente.

Objetivo:

Explorar o papel da ativação plaquetária durante a imunoterapia sublingual em crianças com rinite alérgica.

Método:

Quarenta e duas crianças com rinite alérgica sensibilizadas por ácaros de poeira domiciliar (APD) foram inscritas e receberam extrato de alérgeno de APD para imunoterapia sublingual ou placebo. O soro de diferentes pontos no tempo durante o tratamento foi recolhido e usado para a detecção de fator 4 plaquetário e concentração de beta-tromboglobulina por ensaio imunoenzimático.

Resultados:

Nossos dados mostraram diminuição da expressão de fator 4 plaquetário e proteína beta-tromboglobulina após imunoterapia sublingual de um ano. Além disso, a diminuição dos escores de sintomas e o fator 4 plaquetário sérico e concentrações de proteína beta-tromboglobulina foram relacionados de maneira positiva.

Conclusão:

Durante imunoterapia sublingual, a ativação plaquetária foi inibida significativamente. Os nossos resultados podem indicar que a inibição da ativação de plaquetas dentro da circulação sistêmica é um mecanismo importante durante imunoterapia sublingual.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Beta-Thromboglobulin / Platelet Factor 4 / Sublingual Immunotherapy / Rhinitis, Allergic Type of study: Controlled clinical trial Limits: Child / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2017 Type: Article Affiliation country: China Institution/Affiliation country: Guangzhou Medical College/CN

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Full text: Available Index: LILACS (Americas) Main subject: Beta-Thromboglobulin / Platelet Factor 4 / Sublingual Immunotherapy / Rhinitis, Allergic Type of study: Controlled clinical trial Limits: Child / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2017 Type: Article Affiliation country: China Institution/Affiliation country: Guangzhou Medical College/CN