Development of a mouse computational model for MCNPx based on Digimouse (r) images and dosimetric assays
Braz. J. Pharm. Sci. (Online)
;
53(1): e16092, 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-839463
ABSTRACT
ABSTRACT The aim of this study was to create and test a new mice 3D-voxel phantom named DM_BRA for mice and human first-estimation radiopharmaceutical dosimetry. Previously, the article reviews the state-of-art in animal model development. Images from Digimouse CT database were used in the segmentation and on the generation of the voxelized phantom. Simulations for validation of the DM_BRA model was performed at 0.015, 0.1, 0.5, 1 and 4 MeV photons with heart-source. Specific Absorbed Fractions (SAF) data were compared with literature data. The organ masses of DM_BRA correlated well with existing models based on the same dataset; however, few small organ masses hold significant variations. The SAF data in most simulated cases were statistically equal to a significant level of 0.01 to the reference data.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Computer Literacy
/
Dosimetry
/
Mice
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2017
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Desenvolvimento da Tecnologia Nuclear/BR
/
Universidade Federal de Minas Gerais/BR
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