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Development of a mouse computational model for MCNPx based on Digimouse (r) images and dosimetric assays
Mendes, Bruno Melo; Almeida, Iassudara Garcia de; Trindade, Bruno Machado; Fonseca, Telma Cristina Ferreira; Campos, Tarcísio Passos Ribeiro de.
  • Mendes, Bruno Melo; Centro de Desenvolvimento da Tecnologia Nuclear. Belo Horizonte. BR
  • Almeida, Iassudara Garcia de; Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Ciências e Técnicas Nucleares. Departamento de Engenharia Nuclear. Belo Horizonte. BR
  • Trindade, Bruno Machado; Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Ciências e Técnicas Nucleares. Departamento de Engenharia Nuclear. Belo Horizonte. BR
  • Fonseca, Telma Cristina Ferreira; Centro de Desenvolvimento da Tecnologia Nuclear. Belo Horizonte. BR
  • Campos, Tarcísio Passos Ribeiro de; Universidade Federal de Minas Gerais. Programa de Pós-Graduação em Ciências e Técnicas Nucleares. Departamento de Engenharia Nuclear. Belo Horizonte. BR
Braz. J. Pharm. Sci. (Online) ; 53(1): e16092, 2017. tab, graf
Article in English | LILACS | ID: biblio-839463
ABSTRACT
ABSTRACT The aim of this study was to create and test a new mice 3D-voxel phantom named DM_BRA for mice and human first-estimation radiopharmaceutical dosimetry. Previously, the article reviews the state-of-art in animal model development. Images from Digimouse CT database were used in the segmentation and on the generation of the voxelized phantom. Simulations for validation of the DM_BRA model was performed at 0.015, 0.1, 0.5, 1 and 4 MeV photons with heart-source. Specific Absorbed Fractions (SAF) data were compared with literature data. The organ masses of DM_BRA correlated well with existing models based on the same dataset; however, few small organ masses hold significant variations. The SAF data in most simulated cases were statistically equal to a significant level of 0.01 to the reference data.
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Full text: Available Index: LILACS (Americas) Main subject: Computer Literacy / Dosimetry / Mice Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro de Desenvolvimento da Tecnologia Nuclear/BR / Universidade Federal de Minas Gerais/BR

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Full text: Available Index: LILACS (Americas) Main subject: Computer Literacy / Dosimetry / Mice Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Centro de Desenvolvimento da Tecnologia Nuclear/BR / Universidade Federal de Minas Gerais/BR