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Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)
Malheiros, Camila Krüger Cardoso; Silva, Joyce Sayonara Barbosa; Hofmann, Tânia Cristiane; Messina, Thiane Martins; Manfredini, Vanusa; Piccoli, Jacqueline da Costa Escobar; Faoro, Débora; Oliveira, Luís Flávio Souza; Machado, Michel Mansur; Farias, Fabiane Moreira.
  • Malheiros, Camila Krüger Cardoso; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Silva, Joyce Sayonara Barbosa; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Hofmann, Tânia Cristiane; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Messina, Thiane Martins; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Manfredini, Vanusa; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Piccoli, Jacqueline da Costa Escobar; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Faoro, Débora; Federal University of Santa Maria. Cachoeira do Sul. BR
  • Oliveira, Luís Flávio Souza; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Machado, Michel Mansur; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
  • Farias, Fabiane Moreira; Federal University of Pampa. Faculty of Pharmacy. Uruguaiana. BR
Braz. J. Pharm. Sci. (Online) ; 53(2): e16098, 2017. tab, graf
Article in English | LILACS | ID: biblio-839473
ABSTRACT
ABSTRACT The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile demonstrated the presence of phenolic and flavonoid compounds. The LAECs and Cs1 prevented damage to lipids and proteins at concentrations of 50 and 10 µg/mL. They also showed a scavenging effect on 2,2-diphenyl-1-pricril-hydrazyl (DPPH) radicals in a concentration-dependent manner. Furthermore, no genotoxic effect was observed at concentrations of 10, 5 and 2 µg/mL in the Comet assay. The present study is the first evaluation regarding the characterization of C. speciosa and its safety, and the results demonstrate its antioxidant potential and suggest that its therapeutic use may be relatively safe.
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Full text: Available Index: LILACS (Americas) Main subject: In Vitro Techniques / Malvaceae / Toxicity / Phenolic Compounds / Antioxidants Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pampa/BR / Federal University of Santa Maria/BR

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Full text: Available Index: LILACS (Americas) Main subject: In Vitro Techniques / Malvaceae / Toxicity / Phenolic Compounds / Antioxidants Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Pampa/BR / Federal University of Santa Maria/BR