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IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF, serum and clinic parameters
PIRIM GORGUN, Emine; TOKER, Hulya; KORKMAZ, Ertan Mahir; POYRAZ, Omer.
  • PIRIM GORGUN, Emine; Cumhuriyet University. Faculty of Dentistry. Department of Periodontology. Sivas. TR
  • TOKER, Hulya; Cumhuriyet University. Faculty of Dentistry. Department of Periodontology. Sivas. TR
  • KORKMAZ, Ertan Mahir; Cumhuriyet University. Faculty of Dentistry. Department of Periodontology. Sivas. TR
  • POYRAZ, Omer; Cumhuriyet University. Faculty of Dentistry. Department of Periodontology. Sivas. TR
Braz. oral res. (Online) ; 31: e12, 2017. tab
Article in English | LILACS | ID: biblio-839502
ABSTRACT
Abstract Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin(IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene polymorphisms on the clinical outcomes of non-surgical periodontal therapy and cytokine levels in gingival crevicular fluid(GCF) and serum. Fifty-three patients with GAgP and 50 periodontally healthy individuals were included in this study. Clinical parameters, GCF and blood samples were collected at baseline and at 6-week. Non-surgical periodontal therapy was performed in patients with GAgP. Gene analysis were determined by PCR-RFLP(polymerase chain reaction-restriction fragment length polymorphism) and cytokine levels were determined by enzyme-linked immunosorbent assay(ELISA).GAgP patients showed significant improvement on clinical parameters after periodontal therapy(p<0.05). In the GAgP group, IL-6 GG genotype and G allele frequency were higher than in the control group. GCF IL-6 level was also significantly lower at 6-week in the GAgP group. Higher GCF IL-10 levelswere observed in patients carrying the IL-6 GG genotype than in those carrying the GC+CC genotype at baseline. In conclusion, IL-6(-174) and IL-10(-597) gene polymorphisms were found to be associated with GAgP and genotype distribution did not affect the outcome of non-surgical periodontal therapy, while patients with IL-6(-174) GG genotype had higher levels of GCF IL-10 levels.
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Full text: Available Index: LILACS (Americas) Main subject: Aggressive Periodontitis / Polymorphism, Restriction Fragment Length / Interleukin-6 / Interleukin-10 Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Cumhuriyet University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Aggressive Periodontitis / Polymorphism, Restriction Fragment Length / Interleukin-6 / Interleukin-10 Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: Cumhuriyet University/TR