Your browser doesn't support javascript.
loading
Salivary protein polymorphisms and risk of dental caries: a systematic review
LIPS, Andrea; ANTUNES, Leonardo Santos; ANTUNES, Lívia Azeredo; PINTOR, Andrea Vaz Braga; SANTOS, Diana Amado Baptista dos; BACHINSKI, Rober; KÜCHLER, Erika Calvano; ALVES, Gutemberg Gomes.
  • LIPS, Andrea; Universidade Federal Fluminense. Niteroi. BR
  • ANTUNES, Leonardo Santos; Universidade Federal Fluminense. Niteroi. BR
  • ANTUNES, Lívia Azeredo; Universidade Federal Fluminense. Niteroi. BR
  • PINTOR, Andrea Vaz Braga; Universidade Federal Fluminense. Niteroi. BR
  • SANTOS, Diana Amado Baptista dos; Universidade Federal Fluminense. Niteroi. BR
  • BACHINSKI, Rober; Universidade Federal Fluminense. Niteroi. BR
  • KÜCHLER, Erika Calvano; Universidade Federal Fluminense. Niteroi. BR
  • ALVES, Gutemberg Gomes; Universidade Federal Fluminense. Niteroi. BR
Braz. oral res. (Online) ; 31: e41, 2017. tab, graf
Article in English | LILACS | ID: biblio-839535
ABSTRACT
Abstract Dental caries is an oral pathology associated with both lifestyle and genetic factors. The caries process can be influenced by salivary composition, which includes ions and proteins. Studies have described associations between salivary protein polymorphisms and dental caries experience, while others have shown no association with salivary proteins genetic variability. The aim of this study is to assess the influence of salivary protein polymorphisms on the risk of dental caries by means of a systematic review of the current literature. An electronic search was performed in PubMed, Scopus, and Virtual Health Library. The following search terms were used “dental caries susceptibility,” “dental caries,” “polymorphism, genetics,” “saliva,” “proteins,” and “peptides.” Related MeSH headings and free terms were included. The inclusion criteria comprised clinical investigations of subjects with and without caries. After application of these eligibility criteria, the selected articles were qualified by assessing their methodological quality. Initially, 338 articles were identified from the electronic databases after exclusion of duplicates. Exclusion criteria eliminated 322 articles, and 16 remained for evaluation. Eleven articles found a consistent association between salivary protein polymorphisms and risk of dental caries, for proteins related to antimicrobial activity (beta defensin 1 and lysozyme-like protein), pH control (carbonic anhydrase VI), and bacterial colonization/adhesion (lactotransferrin, mucin, and proline-rich protein Db). This systematic review demonstrated an association between genetic polymorphisms and risk of dental caries for most of the salivary proteins.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Salivary Proteins and Peptides / Dental Caries / Dental Caries Susceptibility Type of study: Etiology study / Prognostic study / Risk factors / Systematic reviews Limits: Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Fluminense/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Salivary Proteins and Peptides / Dental Caries / Dental Caries Susceptibility Type of study: Etiology study / Prognostic study / Risk factors / Systematic reviews Limits: Female / Humans / Male Language: English Journal: Braz. oral res. (Online) Journal subject: Dentistry Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Fluminense/BR