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Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
Paula, Roberta S; Souza, Vinícius C; Machado-Silva, Wilcelly; Almeida, Bruno Ratier S; Daros, Andersen C; Gomes, Lucy; Ferreira, Aparecido P; Brito, Ciro J; Córdova, Cláudio; Moraes, Clayton F; Nóbrega, Otávio T.
  • Paula, Roberta S; Universidade de Brasília. Brasília. BR
  • Souza, Vinícius C; Universidade de Brasília. Brasília. BR
  • Machado-Silva, Wilcelly; Universidade de Brasília. Brasília. BR
  • Almeida, Bruno Ratier S; Universidade de Brasília. Brasília. BR
  • Daros, Andersen C; Universidade de Brasília. Brasília. BR
  • Gomes, Lucy; Universidade de Brasília. Brasília. BR
  • Ferreira, Aparecido P; Universidade de Brasília. Brasília. BR
  • Brito, Ciro J; Universidade de Brasília. Brasília. BR
  • Córdova, Cláudio; Universidade de Brasília. Brasília. BR
  • Moraes, Clayton F; Universidade de Brasília. Brasília. BR
  • Nóbrega, Otávio T; Universidade de Brasília. Brasília. BR
Clinics ; 71(12): 725-732, Dec. 2016. tab, graf
Article in English | LILACS | ID: biblio-840021
ABSTRACT

OBJECTIVES:

The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.

METHODS:

Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).

RESULTS:

Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context.

CONCLUSION:

Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Glucuronidase / Myocardial Infarction Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de Brasília/BR

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Full text: Available Index: LILACS (Americas) Main subject: Glucuronidase / Myocardial Infarction Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade de Brasília/BR