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Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma
Poyrazoglu, Omer Bilgehan; Dulger, Ahmet Cumhur; Gultepe, Bilge Sumbul.
  • Poyrazoglu, Omer Bilgehan; General Surgery. Lokman Hekim Hospital. Van. TR
  • Dulger, Ahmet Cumhur; General Surgery. Lokman Hekim Hospital. Van. TR
  • Gultepe, Bilge Sumbul; General Surgery. Lokman Hekim Hospital. Van. TR
Clinics ; 72(3): 150-153, Mar. 2017. tab, graf
Article in English | LILACS | ID: biblio-840051
ABSTRACT

OBJECTIVE:

Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy.

METHOD:

The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively.

RESULTS:

The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively).

CONCLUSION:

These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Esophageal Neoplasms / Carcinoma, Squamous Cell / Helicobacter pylori / Helicobacter Infections Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: General Surgery/TR

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Full text: Available Index: LILACS (Americas) Main subject: Esophageal Neoplasms / Carcinoma, Squamous Cell / Helicobacter pylori / Helicobacter Infections Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2017 Type: Article Affiliation country: Turkey Institution/Affiliation country: General Surgery/TR