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Human islet xenotransplantation in rodents: A literature review of experimental model trends
Iuamoto, Leandro Ryuchi; Franco, André Silva; Suguita, Fábio Yuji; Essu, Felipe Futema; Oliveira, Lucas Torres; Kato, Juliana Mika; Torsani, Matheus Belloni; Meyer, Alberto; Andraus, Wellington; Chaib, Eleazar; D’Albuquerque, Luiz Augusto Carneiro.
  • Iuamoto, Leandro Ryuchi; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Franco, André Silva; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Suguita, Fábio Yuji; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Essu, Felipe Futema; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Oliveira, Lucas Torres; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Kato, Juliana Mika; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Torsani, Matheus Belloni; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Meyer, Alberto; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Andraus, Wellington; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • Chaib, Eleazar; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
  • D’Albuquerque, Luiz Augusto Carneiro; Universidade de São Paulo. Faculdade de Medicina. Sao Paulo. BR
Clinics ; 72(4): 238-243, Apr. 2017. tab
Article in English | LILACS | ID: biblio-840061
ABSTRACT
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The included studies were recent reports that involved xenotransplantation using human islets in a rodent model. We excluded the studies that related to isotransplantation, autotransplantation and allotransplantation. A total of 34 studies that related to xenotransplantation were selected for review based on their relevance and current data. Advances in the use of different graft sites may overcome autoimmunity and rejection after transplantation, which may solve the problem of the scarcity of islet donors in patients with type 1 diabetes.
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Full text: Available Index: LILACS (Americas) Main subject: Transplantation, Heterologous / Islets of Langerhans Transplantation / Models, Animal / Latent Autoimmune Diabetes in Adults Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Transplantation, Heterologous / Islets of Langerhans Transplantation / Models, Animal / Latent Autoimmune Diabetes in Adults Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR