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Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis / Associação do polimorfismo da proteína tirosina fosfatase não receptora 22 (PTPN22) com endometriose: uma metanálise
Pabalan, Noel; Jarjanazi, Hamdi; Christofolini, Denise Maria; Bianco, Bianca; Barbosa, Caio Parente.
  • Pabalan, Noel; Cebu Doctors’ University. Cebu. CA
  • Jarjanazi, Hamdi; Cebu Doctors’ University. Cebu. CA
  • Christofolini, Denise Maria; Cebu Doctors’ University. Cebu. CA
  • Bianco, Bianca; Cebu Doctors’ University. Cebu. CA
  • Barbosa, Caio Parente; Cebu Doctors’ University. Cebu. CA
Einstein (Säo Paulo) ; 15(1): 105-111, Jan.-Mar. 2017. tab, graf
Article in English | LILACS | ID: biblio-840299
ABSTRACT
ABSTRACT Objective To evaluate PTPN22 C1858T polymorphism and the risk of endometriosis. Methods A meta-analysis of 10 published case-control studies (from four articles), with a total sample of 971 cases and 1,181 controls, was performed. We estimated risk (odds ratio and 95% confidence intervals) of endometriosis associations with the C1858T polymorphism. Results A significant increased risk in all genetic models of the variant T allele with endometriosis (odds ratio 3.14-5.55; p<0.00001-0.002) was found. The analysis without the study whose controls deviated from the Hardy-Weinberg equilibrium exacerbated these effects in the homozygous and recessive models (odds ratio 7.19-9.45; p<0.00001-0.0002). In the Italian subgroup, a significant risk association was found in the homozygous and recessive models (odds ratio 8.72-11.12; p=0.002). Conclusion The associations observed between PTPN22 (C1858T) and the risk of endometriosis suggest this polymorphism might be a useful susceptibility marker for this disease.
RESUMO
RESUMO Objetivo Avaliar o polimorfismo PTPN22 C1858T e o risco de endometriose. Métodos Foi realizada uma metanálise de 10 estudos caso-controle publicados (a partir de quatro artigos), com uma amostra total de 971 casos e 1.181 controles. O risco da associação da endometriose com o polimorfismo C1858T foi estimado em razão de chance e intervalo de confiança de 95%. Resultados Observou-se um aumento de risco significativo em todos os modelos genéticos com o alelo variante T e a endometriose (razão de chance 3,14-5,55; p<0,00001-0,002). A análise sem incluir o estudo, em que os controles não estavam em equilíbrio de Hardy-Weinberg, mostrou aumento significativo nos modelos homozigotos e recessivos (razão de chance 7,19-9,45; p<0,00001-0,0002). No subgrupo italiano, uma associação significativa foi encontrada considerando os modelos homozigoto e recessivo (razão de chance 8,72-11,12; p=0,002). Conclusão As associações observadas entre PTPN22 (C1858T) e o risco de endometriose sugerem que este polimorfismo pode ser um marcador de suscetibilidade para a endometriose.
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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Endometriosis / Protein Tyrosine Phosphatase, Non-Receptor Type 22 Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Female / Humans Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2017 Type: Article Affiliation country: Canada Institution/Affiliation country: Cebu Doctors&#8217; University/CA

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Endometriosis / Protein Tyrosine Phosphatase, Non-Receptor Type 22 Type of study: Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Female / Humans Language: English Journal: Einstein (Säo Paulo) Journal subject: Medicine Year: 2017 Type: Article Affiliation country: Canada Institution/Affiliation country: Cebu Doctors&#8217; University/CA