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A new material to prevent urethral damage after implantation of artificial devices: an experimental study
Lima, Salvador Vilar Correia; Machado, Marcilio Romero; Pinto, Flávia Cristina Morone; Lira, Mariana Montenegro de Melo; Albuquerque, Amanda Vasconcelos de; Lustosa, Eugênio Soares; Silva, Jaiurte Gomes Martins da; Campos J, Olávio.
  • Lima, Salvador Vilar Correia; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Machado, Marcilio Romero; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Pinto, Flávia Cristina Morone; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Lira, Mariana Montenegro de Melo; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Albuquerque, Amanda Vasconcelos de; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Lustosa, Eugênio Soares; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Silva, Jaiurte Gomes Martins da; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
  • Campos J, Olávio; Universidade Federal de Pernambuco. Centro de Ciências da Saúde. Departamento de Cirurgia. BR
Int. braz. j. urol ; 43(2): 335-344, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-840821
ABSTRACT
ABSTRACT Objective To validate the application of the bacterial cellulose (BC) membrane as a protecting barrier to the urethra. Materials and Methods Forty female Wistar rats (four groups of 10) Group 1 (sham), the urethra was dissected as in previous groups and nothing applied around; Group 2, received a 0.7cm strip of the BC applied around the urethra just below the bladder neck; Group 3, received a silicon strip with the same dimensions as in group 2; Group 4, had a combination of 2 and 3 groups being the silicon strip applied over the cellulosic material. Half of the animals in each group were killed at 4 and 8 months. Bladder and urethra were fixed in formalin for histological analysis. Results Inflammatory infiltrates were more intense at 4 months at lymphonodes (80% Grade 2), statistically different in the group 2 compared with groups 1 (p=0.0044) and 3 (p=0.0154). At 8 months, all samples were classified as grade 1 indicating a less intense inflammatory reaction in all groups. In group 2, at 8 months, there was a reduction in epithelial thickness (30±1μm) when com-pared to groups 1 (p=0.0001) and 3 (p<0.0001). Angiogenesis was present in groups 2 and 4 and absent in group 3. In BC implant, at 4 and 8 months, it was significant when comparing groups 4 with 1 (p=0.0159). Conclusion BC membrane was well integrated to the urethral wall promoting tissue remodeling and strengthening based on morphometric and histological results and may be a future option to prevent urethral damage.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bacteria / Urethra / Urethral Diseases / Biocompatible Materials / Cellulose / Urinary Sphincter, Artificial / Prosthesis Implantation Type of study: Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bacteria / Urethra / Urethral Diseases / Biocompatible Materials / Cellulose / Urinary Sphincter, Artificial / Prosthesis Implantation Type of study: Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR