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Tuberculosis associated factors caused by Mycobacterium tuberculosis of the RDRio genotype
Moraes, Eloise Brasil; Slompo, Letícia; Finardi, Amanda Juliane; Silveira, Heloisa Paro Pedro da; Ruiz, Luciana; Gomes, Harrison Magdinier; Richini, Virginia Bodelão; Suffys, Philip; Fortaleza, Carlos Magno Castelo Branco; Cavalcanti, Ricardo; Baptista, Ida Maria Foschiani Dias.
  • Moraes, Eloise Brasil; Instituto Lauro de Souza Lima. Bauru. BR
  • Slompo, Letícia; Instituto Lauro de Souza Lima. Bauru. BR
  • Finardi, Amanda Juliane; Instituto Lauro de Souza Lima. Bauru. BR
  • Silveira, Heloisa Paro Pedro da; Instituto Lauro de Souza Lima. Bauru. BR
  • Ruiz, Luciana; Instituto Lauro de Souza Lima. Bauru. BR
  • Gomes, Harrison Magdinier; Instituto Lauro de Souza Lima. Bauru. BR
  • Richini, Virginia Bodelão; Instituto Lauro de Souza Lima. Bauru. BR
  • Suffys, Philip; Instituto Lauro de Souza Lima. Bauru. BR
  • Fortaleza, Carlos Magno Castelo Branco; Instituto Lauro de Souza Lima. Bauru. BR
  • Cavalcanti, Ricardo; Instituto Lauro de Souza Lima. Bauru. BR
  • Baptista, Ida Maria Foschiani Dias; Instituto Lauro de Souza Lima. Bauru. BR
Mem. Inst. Oswaldo Cruz ; 112(3): 182-187, Mar. 2017. tab
Article in English | LILACS | ID: biblio-841777
ABSTRACT
BACKGROUND Tuberculosis (TB) continues to be a disease that affects many countries around the world, including Brazil. Recently, a subtype of Latin American-Mediterranean family strain was identified and characterised by RDRio. The strain has been associated with different characteristics of the disease. OBJECTIVES In the present study we investigated the association of epidemiological, clinical, radiological and bacteriological variables with pulmonary tuberculosis caused by RDRioMycobacterium tuberculosis strain in large regions of São Paulo. METHODS We conducted a cross-sectional study in 530 patients with pulmonary tuberculosis, diagnosed using sputum culture, from two regions of the São Paulo state in Brazil. The samples were brought to São Paulo reference laboratories for epidemiological, clinical, radiological and bacteriological analyses, and the data were obtained from a TB notification system. RDRio genotyping and Spoligotyping of the samples were performed. For the analysis of the categorical variables we used the chi-square test or the Fisher’s exact test, and for the continuous variables, the Mann-Whitney test. In addition, a logistic regression was used for multivariate analysis. Differences with p < 0.05 were considered significant. FINDINGS The RDRio deletion was identified in 152 (28.7%) samples. In the univariate analysis, both the age groups above 25 years and alcohol consumption were associated with the RDRio deletion. The multivariate analysis confirmed the association of the RDRio deletion with the age groups 25-35 years old [OR 2.28 (1.02-5.07; p = 0.04)] and 36-60 years old (OR 2.36 (1.11-5.05); p = 0.03], and also with alcohol consumption [OR 1.63 (1.05-2.54); p = 0,03]. MAIN CONCLUSIONS In this study, we identified new factors associated with the M. tuberculosis of the RDRio deletion strains infection.
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Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Instituto Lauro de Souza Lima/BR

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Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2017 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Instituto Lauro de Souza Lima/BR