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Analysis of the seroprevalence of and factors associated with Chagas disease in an endemic area in Northeastern Brazil
Freitas, Erlane Chaves; Oliveira, Maria de Fátima; Vasconcelos, Arduina Sofia Ortet de Barros; Silva >Filho, José Damião da; Viana, Carlos Eduardo Menezes; Gomes, Kátia Cristina Morais Soares; Cavalcanti, Luciano Pamplona de Góes.
  • Freitas, Erlane Chaves; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
  • Oliveira, Maria de Fátima; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
  • Vasconcelos, Arduina Sofia Ortet de Barros; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
  • Silva >Filho, José Damião da; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
  • Viana, Carlos Eduardo Menezes; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
  • Gomes, Kátia Cristina Morais Soares; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
  • Cavalcanti, Luciano Pamplona de Góes; Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Programa de Pós-Graduação em Patologia. Fortaleza. BR
Rev. Soc. Bras. Med. Trop ; 50(1): 44-51, Jan.-Feb. 2017. tab
Article in English | LILACS | ID: biblio-842825
ABSTRACT
ABSTRACT

INTRODUCTION:

Chagas disease (CD) is currently considered a neglected disease; hence, identifying the factors associated with its high prevalence is essential. This study aimed to identify the seroprevalence of and the possible factors associated with CD in inhabitants of the City of Limoeiro do Norte, Northeastern Brazil.

METHODS:

Between April and November 2013, blood collection was conducted and a semi-structured questionnaire was administered. Blood samples that showed positive or possible serology for anti-Trypanosoma cruzi antibodies based on indirect immunofluorescence, hemagglutination indirect, and an enzyme-linked immunosorbent assay were analyzed. Associations between CD positivity and the study variables were analyzed using prevalence ratios (PR) with 95% confidence intervals (CI).

RESULTS:

A total of 812 individuals were analyzed, of which T. cruzi seropositivity was determined in 4.2% (34 individuals). Sociodemographic variables showing a significant association with T. cruzi positivity included age >50 years (PR = 27.6; 95% CI = 6.66-114.4), elementary level education (PR = 5.15; 95% CI = 1.83-14.47), and retirement (PR = 7.25; 95% CI = 3.72-14.14). Positivity for T. cruzi was 6.17 times higher in those who had a history of living in rammed earth houses compared with those who did not (95% CI = 2.19-17.37). There was no evidence of vertical transmission in the individuals studied. Among the individuals infected with T. cruzi, the majority reported having a comorbidity (p < 0.01).

CONCLUSIONS:

This study demonstrated the seroprevalence of CD and identified factors associated with a high prevalence of CD.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma cruzi / Antibodies, Protozoan / Chagas Disease / Endemic Diseases Type of study: Diagnostic study / Prognostic study / Qualitative research / Risk factors Limits: Aged80 / Animals / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma cruzi / Antibodies, Protozoan / Chagas Disease / Endemic Diseases Type of study: Diagnostic study / Prognostic study / Qualitative research / Risk factors Limits: Aged80 / Animals / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Ceará/BR