Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
Rev. bras. farmacogn
;
27(2): 214-219, Mar.-Apr. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-843812
ABSTRACT
ABSTRACT This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20 mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80 mg/kg). Moreover, the extract prevented the occurrence of secondary lesions associated to this pharmacological model.
Full text:
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Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2017
Type:
Article
/
Project document
Affiliation country:
Mexico
Institution/Affiliation country:
Universidad de Guanajuato/MX
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