Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
Rev. bras. farmacogn
;
27(2): 170-174, Mar.-Apr. 2017. tab, graf
Article
in English
| LILACS
| ID: biblio-843814
ABSTRACT
ABSTRACT A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids irilone 4'-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4'-O-β-D-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1,1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 µM.
Full text:
Available
Index:
LILACS (Americas)
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2017
Type:
Article
Affiliation country:
Saudi Arabia
Institution/Affiliation country:
Taibah University/SA
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