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Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
Ibrahim, Sabrin; Al-Ahdal, Abdulrahman; Khedr, Amgad; Mohamed, Gamal.
  • Ibrahim, Sabrin; Taibah University. College of Pharmacy. Department of Pharmacognosy and Pharmaceutical Chemistry. Al Madinah Al Munawwarah. SA
  • Al-Ahdal, Abdulrahman; Taibah University. College of Pharmacy. Department of Pharmacognosy and Pharmaceutical Chemistry. Al Madinah Al Munawwarah. SA
  • Khedr, Amgad; Taibah University. College of Pharmacy. Department of Pharmacognosy and Pharmaceutical Chemistry. Al Madinah Al Munawwarah. SA
  • Mohamed, Gamal; Taibah University. College of Pharmacy. Department of Pharmacognosy and Pharmaceutical Chemistry. Al Madinah Al Munawwarah. SA
Rev. bras. farmacogn ; 27(2): 170-174, Mar.-Apr. 2017. tab, graf
Article in English | LILACS | ID: biblio-843814
ABSTRACT
ABSTRACT A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids irilone 4'-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4'-O-β-D-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1,1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 µM.


Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2017 Type: Article Affiliation country: Saudi Arabia Institution/Affiliation country: Taibah University/SA

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Full text: Available Index: LILACS (Americas) Language: English Journal: Rev. bras. farmacogn Journal subject: Pharmacy Year: 2017 Type: Article Affiliation country: Saudi Arabia Institution/Affiliation country: Taibah University/SA