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Secondary myeloid neoplasms: bone marrow cytogenetic and histological features may be relevant to prognosis
Tanizawa, Roberta Sandra da Silva; Zerbini, Maria Claudia Nogueira; Rosenfeld, Ricardo; Kumeda, Cristina Aiko; Azevedo, Raymundo Soares; Siqueira, Sheila Aparecida Coelho; Velloso, Elvira Deolinda Rodrigues Pereira.
  • Tanizawa, Roberta Sandra da Silva; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Zerbini, Maria Claudia Nogueira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Rosenfeld, Ricardo; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Kumeda, Cristina Aiko; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Azevedo, Raymundo Soares; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Siqueira, Sheila Aparecida Coelho; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
  • Velloso, Elvira Deolinda Rodrigues Pereira; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo. BR
Rev. bras. hematol. hemoter ; 39(1): 4-12, Jan.-Mar. 2017. tab, graf
Article in English | LILACS | ID: biblio-843954
ABSTRACT
Abstract

Background:

Secondary myeloid neoplasms comprise a group of diseases arising after chemotherapy, radiation, immunosuppressive therapy or from aplastic anemia. Few studies have addressed prognostic factors in these neoplasms.

Method:

Forty-two patients diagnosed from 1987 to 2008 with secondary myeloid neoplasms were retrospectively evaluated concerning clinical, biochemical, peripheral blood, bone marrow aspirate, biopsy, and immunohistochemistry and cytogenetic features at diagnosis as prognostic factors. The International Prognostic Scoring System was applied. Statistical analysis employed the Kaplan–Meier method, log-rank and Fisher's exact test.

Results:

Twenty-three patients (54.8%) were male and the median age was 53.5 years (range 4–88 years) at diagnosis of secondary myeloid neoplasms. Previous diseases included hematologic malignancies, solid tumors, aplastic anemia, autoimmune diseases and conditions requiring solid organ transplantations. One third of patients (33%) were submitted to chemotherapy alone, 2% to radiotherapy, 26% to both modalities and 28% to immunosuppressive agents. Five patients (11.9%) had undergone autologous hematopoietic stem cell transplantation. The median latency between the primary disease and secondary myeloid neoplasms was 85 months (range 23–221 months). Eight patients were submitted to allogeneic hematopoietic stem cell transplantation to treat secondary myeloid neoplasms. Important changes in bone marrow were detected mainly by biopsy, immunohistochemistry and cytogenetics. The presence of clusters of CD117+ cells and p53+ cells were associated with low survival. p53 was associated to a higher risk according to the International Prognostic Scoring System. High prevalence of clonal abnormalities (84.3%) and thrombocytopenia (78.6%) were independent factors for poor survival.

Conclusion:

This study demonstrated that cytogenetics, bone marrow biopsy and immunohistochemistry are very important prognostic tools in secondary myeloid neoplasms.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Myelodysplastic Syndromes / Secondary Effect / Neoplasms, Second Primary Type of study: Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Rev. bras. hematol. hemoter Journal subject: Hematology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Myelodysplastic Syndromes / Secondary Effect / Neoplasms, Second Primary Type of study: Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Rev. bras. hematol. hemoter Journal subject: Hematology Year: 2017 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR