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Elección del mejor antidepresivo en pacientes con cáncer de mama en tratamiento con tamoxifeno: revisión de la evidencia básica y clínica / Antidepressants agents in breast cancer patients using tamoxifen: review of basic and clinical evidence
Irarrázaval O, María Elisa; Gaete G, Leonardo.
  • Irarrázaval O, María Elisa; Centro Médico Los Juncos. Santiago. CL
  • Gaete G, Leonardo; Centro Médico Los Juncos. Santiago. CL
Rev. méd. Chile ; 144(10): 1326-1335, oct. 2016. ilus, tab
Article in Spanish | LILACS | ID: biblio-845448
ABSTRACT
Tamoxifen (Tmf), is a standard of care for women with estrogen receptor positive (ER+) breast cancer. Endoxifen is a Tmf metabolite generated by cytochrome P450 2D6 (CYP2D6). Antidepressive agents (AD) are often prescribed to women with breast cancer not only for depression, but also for anxiety and hot flashes. Some AD are substrates or inhibitors of the Tmf metabolic pathway. Therefore there may be interactions when Tmf and AD are prescribed simultaneously. Oncologic protection afforded by Tmf may become less effective or null when AD are indicated, especially in poor metabolizing patients. We performed an update of the literature about the criteria for choosing AD in women receiving Tmf. Tricyclic AD, paroxetine and fluoxetine should be avoided in patients receiving Tmf, because they are strong inhibitors of CYP2D6. Bupropion, duloxetine and sertraline are only moderate inhibitors of the cytochrome and are not contraindicated. Citalopram, desvenlafaxine, escitalopram, milnacipran and venlafaxine are recommended, because they do not influence the metabolism and clinical efficacy of Tmf and have fewer drug interactions. However, other additional pharmacological and clinical issues should be considered when choosing an antidepressant in women with breast cancer.
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Full text: Available Index: LILACS (Americas) Main subject: Tamoxifen / Breast Neoplasms / Antineoplastic Agents, Hormonal / Antidepressive Agents Type of study: Etiology study / Risk factors Limits: Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2016 Type: Article Affiliation country: Chile Institution/Affiliation country: Centro Médico Los Juncos/CL

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Full text: Available Index: LILACS (Americas) Main subject: Tamoxifen / Breast Neoplasms / Antineoplastic Agents, Hormonal / Antidepressive Agents Type of study: Etiology study / Risk factors Limits: Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2016 Type: Article Affiliation country: Chile Institution/Affiliation country: Centro Médico Los Juncos/CL