Para entender la acción de cortisol en inflamación aguda: una mirada desde la glándula suprarrenal hasta la célula blanco / Understanding cortisol action in acute inflammation: a view from the adrenal gland to the target cell
Rev. méd. Chile
;
145(2): 230-239, feb. 2017. ilus
Article
in Spanish
| LILACS
| ID: biblio-845528
ABSTRACT
Glucocorticoids (cortisol in humans) are essential for numerous biological functions. Among critically ill patients, therapy with cortisol has gained strength in recent years, but clinical results have been mixed. A series of events, that may explain the diversity of clinical responses, occur from the synthesis of cortisol in the adrenal gland to the activation of the cortisol receptor by the hormone when it enters the nucleus of the target cell. Some of these events are revised; a proposition for identifying critically ill patients who may benefit with this therapy is suggested.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pituitary-Adrenal System
/
Hydrocortisone
/
Adrenal Insufficiency
/
Hypothalamo-Hypophyseal System
/
Inflammation
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2017
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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