Características clínicas de pacientes con déficit selectivo de IgA en el hospital infantil municipal de Córdoba, periodo 2010-2013 / Clinical features of patients with selective Iga deficiency In municipal hospital children of Córdoba, period 2010-2013
Alerg. inmunol. clin
;
34(1-2): 4-7, 2014. ilus, graf
Article
in Spanish
| LILACS
| ID: biblio-868708
RESUMEN
Introducción:
el déficit selectivo de IgA (DsIgA) es la inmunodeficiencia primaria más frecuente, caracterizada por nivelesséricos de inmunoglobulina A (IgA) menores a 7 mg/dl en pacientes mayores a 4 años con niveles normales de otros isotipos de inmunoglobulinas. Aunque la mayoría de los individuos sona sintomáticos, cerca de un tercio padecen infecciones recurrentes, alergia o autoinmunidad.Objetivo:
Principal determinar características clínicas asociadas al DsIgA. Secundario analizar los valores de inmunoglobulina G (IgG) e inmunoglobulina M (IgM) de los pacientes.Materiales ymétodos:
Se revisaron en forma retrospectiva registros de laboratorio e historias clínicas de 24 pacientes que cumplieron con los criterios diagnósticos de DsIgA.Resultados:
Se observó que 17 pacientes (71%) presentaban fenó-menos alérgicos, 13 pacientes (54%) enfermedades autoinmunes y 7 pacientes (29%) infecciones recurrentes al momento de diagnóstico del DsIgA. Además se pudo ver un aumento de IgG e IgMen un 38% y 46% de los pacientes, respectivamente.Conclusión:
Observamos que la principal manifestación clínica fue la alergia, y que un grupo de pacientes tenía elevadas sus inmunoglobulinas séricas.ABSTRACT
Introduction:
selective IgA deficiency (IgAD) is considered as the most common primary immunodeficiency, is defined as a serum IgA of less than 7mg/dl, with normal serum IgG and IgM levels in patients older than 4 years with other wise normal immune system. Although the majority of affected individuals are asymptomatic, a third of patients are symptomatic and suffer from recurrent infections, allergies and autoimmune diseases.Aim:
To investigate the clinical characteristics of children with IgAD and analyse the levels of IgG and IgM of the patients. Materials andmethods:
The clinical and laboratory information from medical records of 24 children with IgAD were studied retrospectively.Results:
17 (71%) patients had allergic disorders, 13 (54%) patients had autoimmune disorders and 7 (29%) patients had infectious diseases at the moment of the diagnosis of IgAD. Serum IgG and IgM levels were increased in 38 % and 46 % of patients, respectively.Conclusions:
we found that allergic disorders were the most common clinical manifestation and group of patients had increased levels of serum immunoglobulins.
Full text:
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Index:
LILACS (Americas)
Main subject:
Argentina
/
Child
/
Retrospective Studies
/
IgA Deficiency
/
Asymptomatic Infections
/
Hospitals, Pediatric
/
Immunologic Deficiency Syndromes
Type of study:
Observational study
/
Risk factors
Limits:
Child
/
Humans
Country/Region as subject:
South America
/
Argentina
Language:
Spanish
Journal:
Alerg. inmunol. clin
Journal subject:
Allergy and Immunology
/
Fenmenos do Sistema Imunol¢gico
/
Hipersensibilidade
Year:
2014
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Laboratorio de Inmunología del Hospital Infantil Municipal de Córdoba/AR
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