Agranulocitosis por clozapina: un paradigma de la relación costo-beneficio / Clozapine-induced agranulocytosis: A Paradigm of the cost-benefit relationship
Psicofarmacologia (B. Aires)
;
11(71): 27-32, nov. 2011. ilus, graf
Article
in Spanish
| LILACS
| ID: biblio-869260
RESUMEN
La clozapina es una herramienta terapéutica altamente eficaz utilizada en el tratamiento sintomático de la esquizofrenia. A pesar de los beneficios que brinda en dichos pacientes, su uso se ha restringido debido a la aparición potencialmente letal de agranulocitosis, un efecto adverso idiosincrático, cuya fisiopatología permanece aún desconocida. A través de esta revisión bibliográfica, se analizarán los principales aspectos clínicos de este efecto adverso, se expondrán las actuales indicaciones del fármaco y se evaluará el costo-beneficio de su indicación.
ABSTRACT
Clozapine is a highly effective therapeutic tool that is used for the treatment of schizophrenia symptoms. Despite its benefits on patients with such disease, its use has been restricted due to the potentially lethal appearance of agranulocytosis, an idiosyncratic adverse effect whose pathology still remains unknown. In this review, the author will analyze the main clinical aspects of this adverse effect, describe the current prescriptions of this pharmacological drug and evaluate the cost-benefit of its prescription.
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Index:
LILACS (Americas)
Main subject:
Schizophrenia
/
Cost-Benefit Analysis
/
Clozapine
/
Agranulocytosis
Type of study:
Health economic evaluation
Language:
Spanish
Journal:
Psicofarmacologia (B. Aires)
Journal subject:
Pharmacology
/
Psychology
/
Psychiatry
Year:
2011
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad de Buenos Aires/AR
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